Further Lignans from Ocotea duckei

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Crude ethanolic extract, lignoid fraction and yangambin from Ocotea duckei (Lauraceae) show antileishmanial activity.

Crude ethanolic extract, lignoid fraction and the purified compound yangambin were obtained from Ocotea duckei (Lauraceae) and their antileishmanial activity was tested against promastigote forms of Leishmania chagasi and Leishmania amazonensis cultivated in Schneider medium, supplemented with 20% of fetal bovine serum. All substances presented antileishmanial activity with IC50 values of 135.7...

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Yangambin cytotoxicity: a pharmacologically active lignan obtained from Ocotea duckei vattimo (Lauraceae).

The in vitro cytotoxic potential of yangambin was evaluated. Yangambin is a pharmacologically active furofuran lignan obtained from the leaves of Ocotea duckei. It is the major compound from the lignoids fraction. Yangambin presented low cytotoxicity in all in vitro models analyzed. Its cytotoxicity to murine macrophages was measured by the Trypan blue dye exclusion test and MTT reduction assay...

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Lignans from Kadsura angustifolia.

A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic...

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APORPHINE ALKALOIDS FROM Ocotea macrophylla (LAURACEAE)

Four aporphine alkaloids from the wood of Ocotea macrophylla (Lauraceae) were isolated and characterized as (S)-3-methoxynordomesticine (1), (S)-N-ethoxycarbonyl-3-methoxy-nordomesticine (2), (S)-N-formyl-3-methoxy-nordomesticine (3) and (S)N-methoxycarbonyl-3-methoxy-nordomesticine (4); alkaloids 2-4 are being report for the first time. The structure the isolated compounds were determined base...

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Lignans from Cupressus lusitanica (Cupressaceae).

Cupressus lusitanica Mill. (Family: Cupressaceae), commonly known as &Mexican cypress' or &Cedar-of-Goa', is an ornamental plant found extensively in Mexico, El Salvador, Guatemala and Honduras, and also in other parts of North and South America (USDA-ARS-GRIN database, 1999). Plant material was collected from Costa Rica and supplied by Biotics Limited, University of Sussex, Brighton, UK. A vou...

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ژورنال

عنوان ژورنال: Pharmaceutical Biology

سال: 1999

ISSN: 1388-0209,1744-5116

DOI: 10.1076/phbi.37.2.144.6084